ReStore! Energy Ingredients

Vitamin B6 is a supplement that is involved in a significant number of vital bodilyfunctions. It is a co-enzyme involved in the metabolism of protein andcarbohydrates, and aids in the formation of blood cells. Vitamin B6 is also involved in the synthesis of neurotransmitters and prostaglandins-and is necessary for proper B12 absorption.

There appears to be an inverse relationship of vitamin B6 and homocysteine. This is important because homocysteine is a known risk factor in heart disease, and patients with diabetes have a significant increased risk for heart disease. Peripheral neuropathy, which affects many patients with diabetes, is a known result of pyridoxine deficiency in some cases.11

The two major forms of vitamin B6 are pyridoxine and pyridoxamine. They are converted in the liver to a co-factor, pyridoxy-5-phosphate (PCP) that is a main component of the essential metabolic functions of vitamin B6. PCP is utilized to help with the conversion of glycogen to glucose in the liver, and helping to inhibit platelet aggregation.

Stress can wreak havoc on blood glucose control. Vitamin B6 works to control stress because it is used in the synthesis of essential neurotransmitters. This B vitamin has, in fact, been utilized for years in medicine by physicians to help patients who undergo stress.

Vitamin B5 or pantothenic acid is a vitamin found in numerous cellular reactions in the body. It is intimately involved in the breakdown of fat and protein. It helpsmake red blood cells, sex hormones, and adrenal hormones. Vitamin B5 is used inthe manufacture of acetylcholine, an extremely important neurotransmitter.

Vitamin B5 is also part of an enzyme that helps with fat burning (Co-Enzyme A). It is also involved with the manufacturing of melatonin in the body, which is responsible for a good sleep cycle. It has been dubbed the "anti-stress" vitamin because it is involved in regulating hormones in the adrenal cortex, which are activated when the body is under stress.

For patients with diabetes, lipids are a concern because high lipids are a risk factor for heart disease, and patients with diabetes have a greater risk for heart problems. In numerous studies, Vitamin B5 has been shown to help correct dyslipidemia, keeping lipids lower. 12. Given this fact, coupled with all the other positive benefits that have been published about vitamin B5, it is an ideal choice for the ReStore Diabetes Energy Drink formula.

Thiamine is used in many different areas of metabolism in the body. Thiaminehelps enhance circulation, is utilized for blood formation, and aids in carbohydrate metabolism. It is required for a healthy nervous system, and is used in the biosynthesis of neurotransmitters such as acetylcholine and GABA. It is alsonecessary for hydrochloric acid production, and thus plays a role in digestion. Minor deficiencies in thiamine can cause symptoms such as fatigue, irritability,forgetfulness, and loss of appetite. Patients with diabetes need to pay particular attention to circulatory health as well as nerve health, as these patients are prone to heart problems, neuropathy, and kidney problems.

A study on the benefits of thiamine to prevent diabetic nephropathy was published in 2003, and helped support the need of this important vitamin for patients with diabetes. Thiamine is a water-soluble vitamin, and therefore what the body cannot use is excreted in the urine. Toxicity of this vitamin is very rare. A very important studydone in August 2007 at Warwick University in England showed that patients with diabetes expelled thiamine at fifteen times the normal rate. This shows the need for more thiamine in patients with diabetes, and may account for the nerve problems and fatigue seen in many patients with diabetes. Thiamine is also destroyed in the process of cooking, and is not found to a greatextent in processed foods. This further provides clear evidence that thiamine is an important supplement for overall good health.

Vitamin A is necessary for bone growth, testicular function, ovarian function,embryonic development, and differentiation of tissues. It is essential for healthy vision.

Vision problems such as cataracts and retinopathy are more prevalent in patients with diabetes. Diabetic retinopathy is a common cause of blindness and in the U. S. it is the leading cause of new blindness in those of occupational age. Antioxidants such as vitamin A offer great benefits for eye health by protecting against the effects of aging. Aging and diabetes both cause increased free radical damage and a gradual decline in circulation and oxygenation of tissues.

A study called The Baltimore Longitudinal Study of Aging showed that anti-oxidants like vitamin A offer help with eye health and slow down problems like macular degeneration. In the pigment epithelial tissues of the retina, vitamin A compounds bind to opsin proteins in the rods and cones; which produce the photosensitive proteins that allow us to see better at night. Clearly as an anti-oxidant and for overall eye health Vitamin A is a solid choice as a supplement for patients with diabetes.

This B vitamin has been the subject of numerous clinical studies relating to diabetes. Niacinamide is structurally similar to niacin, but behaves somewhat differently in its actions on the body. It is a co-enzyme; involved in tissue respiration, lipid metabolism, and glycogenolysis. It does not cause flushing as niacin does because it behaves a bit differently in the body.

The excitement about niacinamide revolves around the fact that it may indeed protect islet cells from destruction, thereby possibly preventing diabetes. This is an exciting breakthrough, and is backed by many clinical studies. One impressive study was made by Elliott and co-workers. Diabetes can in part be caused by an autoimmune reaction where the body starts destroying islet cells, which can contribute to the cause of diabetes.

This study has gotten the attention of many prestigious institutions, and currently there is a large placebo controlled study called ENDIT-in Europe, where niacinamide is being studied in preventing/delaying beta cell destruction in patients. Along with its many roles in metabolism as a co-enzyme, this is a supplement that can have positive benefits for patients with diabetes.

Biotin is one of the more recently discovered water-soluble B vitamins. It is essential for the activity of many enzyme systems, and plays a strong role in the production of energy from the metabolism of carbohydrates and fats.

The mechanism by which biotin works for patients with diabetes is that biotin stimulates liver glucokinase activity, increasing insulin production, and enhancing glucose uptake in muscle cells.5 A Japanese study did show ithat in diabetic patients, there is an inverse relationship between blood sugars and biotin. The study found that as blood sugar levels went up, levels of biotin went down. Researchers took this study a step further by giving extra biotin to patients with diabetes, and their results showed that blood sugar levels went down with biotin supplementation.

Biotin is found in many foods, but generally in lower amounts than other watersoluble vitamins. This vitamin is destroyed by certain food-processing techniques such as canning and heat curing.

Vitamin E is a major fat-soluble anti-oxidant that can pass through humanmembranes and enter cells. Fat-soluble anti-oxidants protect fatty tissues fromspoiling or turning rancid, which scientists call lipid per-oxidation. This "free radicaldamage" may contribute to diabetes by either impairing insulin secretion or increasing insulin resistance. In one study to support this theory researchers assessed the diets of 2,285 men and 2,019 women who did not yet have diabetes. Their conclusion was people consuming the highest amount of vitamin E were 31 percent less likely to develop diabetes than those consuming the lowest amounts (Diabetes Care, 2004-27:362-366).

Vitamin E has had more than 50 years of clinical study, which document its'positive effects on overall health, from helping to lower serum cholesterol to helping keep patients "heart healthy". In fact, a new study led by Dr. Andrew Levy at Technion-Israel Institute ofTechnology found that diabetic patients might reduce their risk of dying from heart disease with the help of vitamin E. A team led by Dr. Levy found that diabetic patients with the 2-2 form of haptoglobin (a blood protein that increases the risk of heart attacks for diabetics by 500 percent) reduced their risk of heart attack by 43 percent, and their risk of dying from heart disease by 55 percent when they took 400IU of vitamin E daily.

Vitamin C is a water-soluble vitamin best known for its effect on the commoncold and in wound healing. Indeed, Linus Pauling's work with vitamin C has been published in thousands of publications worldwide. Vitamin C is an anti-oxidant-and by virtue of this fact is helpful, as we know that diabetes causes the body to make several oxidative by-products that can cause harm to the body, leading to the complications of diabetes that we see. Vitamin C is also used in the production of neurotransmitters that are essential in avoiding depression.

With regard to helping wound healing, vitamin C forms collagen and helps repair tissue. Many patients with diabetes have trouble with wound healing and this vitamin should be of benefit to them. It has been shown that people with diabetes have lower plasma levels of vitamin C (30 percent) than people who do not. Vitamin C has been shown to reduce the activity of the enzyme aldose reductase. This enzyme is responsible for the accumulation of sorbitol in the eyes, nerves, and kidneys of people with diabetes, and is believed to be responsible for complications from this disease.

Vitamin C is required for the synthesis of the body's stress hormones in the adrenal glands, including epinephrine, norepinephrine, cortisol, and histamine. Fever, burns, exposure to cold, and physical trauma all require larger doses of this vitamin. Study results suggest that patients with diabetes have a greater need for vitamin C 2. This would make sense, as patients with diabetes are exposed to stress chronically.

Folic acid, or vitamin B9 was first isolated from spinach leaves in 1964. Since then exciting research has documented the benefits of this important vitamin. Folic acid is essential for the synthesis of adenine ands thymine, two of the four nucleic acids that make up our genetic material. This is why adequate folic acid intake is crucial for pregnant women.

In addition, folic acid is also required for the proper metabolism of methionine, which is an amino acid found primarily in animal proteins. This is an extremely important role because in this metabolic process folic acid prevents the buildup of homocysteine. The idea that homocysteine may be a strong risk factor for coronary heart disease has been studied since 1986. Studies confirm that high homocysteine levels not only increase the risk of coronary heart disease, but also raise the risk of heart attack, strokes, and peripheral vascular disease. 17 Because diabetes is an independent risk factor for heart disease, folic acid is an important supplement in the patient with diabetes.

As folic acid has been the subject of numerous studies over the years, it has also been found to not only be important for heart health, but also to mental health as well. At University of York, a defieciency of folic acid was linked to a 40% increase of depression. Research at the Cleveland Clinic Foundation has found that patients with end stage renal disease have very high levels of homocysteine, suggesting that adequate folic acid is necessary to possibly help prevent kidney disease.

Chromium is an essential trace mineral found in meats, fish, coffee, tea, and some bread such as wheat bread. More than 30 years of research have shown that chromium works with insulin to shuttle blood sugar into body and brain cells before it can be converted into fat. This mineral also helps mitochondria turn sugar into energy.

Typical Western diets require more chromium than they provide. This is partly due to the fact that diets high in refined carbohydrates cause increased urine excretion of chromium. The body cannot make chromium; it must be obtained through diet or supplementation. The U.S. Department of Agriculture's analysis of food intake suggests that the average American diet is low in chromium.18 In addition, aging is associated with a 25-40 percent drop in tissue chromium and may be implicated in type 2 diabetes.19 Chromium is nonessential for plants so they have no incentive to concentrate it.

A study presented at the 18th International Diabetes Federation Congress in Paris found that chromium picolinate might improve insulin sensitivity in patients with type 2 diabetes. There have also been studies done relating some chromium supplements to lowering risk factors for patients with type 2 diabetes.

It is clear that chromium is in not only seen in supplements such as vitamins, but can be found in many weight loss products as well. Its role in carbohydrate metabolism has been clinic ally accepted for many years.

drsi™RESTORE ENERGY comes in powdered form, which is mixed with 9-12 ounces of water. The advantage of the powder forrm is that unlike pills, ReStore is immediately bio-available, and its effects can be felt almost immediately. The addition of calcium carbonate allows for the fastest, most effective absorption rate of the vitamin complex, which also adds to the formula’s efficacy.

Many people with diabetes suffer from gastropuresis, which can make digestion difficult.  ReStore’s ingredient profile has been very carefully researched to give the most benefit to the diabetic patient, and in the slightly effervescent powdered form ReStore is a more attractive alternative to vitamin capsules and pills.